Photolabile group for 50-OH protection of nucleosides: synthesis and photodeprotection rate
نویسندگان
چکیده
In this paper, we described the properties of a new photolabile group, 2-(3,4-methylenedioxy-6-nitrophenyl)propoxycarbonyl, MNPPOC. In spite of moderate yields of synthesis, photolytic properties could be analyzed for 50-OH protected T and dA. The half-lives (t1/2) 11 and 12 s were found, respectively, with a good recovery of the corresponding deprotected deoxynucleoside (95±99%). The photolysis rate of this new photolabile group was ®ve-fold faster than the MeNPOC one. # 2001 Elsevier Science B.V. All rights reserved.
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